Thursday, October 29, 2015

Second Opinions on Costly Surgery


The Startups That Give You a Second Opinion on Costly Surgery

Employers say double-checking doctors' orders can control medical costs
John Tozzi
August 20, 2015

Photograph: Getty Images


In the window before his kids wake up and he has to go to work, Dr. Gregory Gebauer helps people he's never met avoid needless surgery. That's when the Florida spine surgeon reads charts and examines MRI or X-ray scans referred to him through a company called Grand Rounds, a San Francisco startup that promises to save employers money and help their workers find better care. He often finds that patients have been given an inaccurate diagnosis or recommended for an operation unlikely to help them. "There’s certainly a time and place for surgery, but usually, at least in my practice, I recommend other things before jumping to surgery," says Gebauer, who has reviewed more than 50 cases from patients across the U.S.

The full-time orthopedic surgeon is one of an army of expert doctors who moonlight remotely for Grand Rounds, which has raised $106 million in venture capital, including a $55 million round announced today. The four-year-old company, which takes its name from the term for expert presentations doctors give to their colleagues, has signed such clients as Comcast, Costco, and Jamba Juice. About 60 percent of large employers plan to offer tools like second-opinion services or other advice to help patients make medical decisions in 2016, up from 48 percent this year, according to a survey of 140 large companies by the National Business Group on Health. Grand Rounds Chief Executive Owen Tripp says about two-thirds of all its reviews lead to changes in diagnosis or treatment. The number "still shocks me,” Tripp says. "Most of the frontline care we deliver today is either inadequate or ineffective."

Grand Rounds and its competition—companies such as Best Doctors, 2nd.MD, and Accolade—are trying to help employers deal with a problem that plagues American health care: wild deviations in care among different providers and regions. For example, patients in Bradenton, Fla., get a controversial spinal fusion surgery for lower-back problems almost 14 times more frequently than patients in Bangor, Me., according to data from the Dartmouth Atlas of Health Care, which tracks disparities in care.


That kind of variation is at least partly responsible for America’s outsize medical costs, which are higher per capita than anywhere else. It’s some combination of errors, differences in professional judgement, and a payment system that often creates incentives for doctors to prescribe treatments most lucrative for them. "There is a tremendous amount of misdiagnosis that goes on," says Lewis Levy, chief quality officer at Best Doctors, which contracts with 50,000 physicians to do remote second opinions for clients. The doctors are recommended by peers as leaders in their field.

Second-opinion services allow employers to take a softer approach than enforcing strict rules requiring workers to get permission before seeking costly treatments. Most companies that offer services like Grand Rounds and Best Doctors make them voluntary, and though there may be incentives to get a medical decision reviewed, workers can usually skip the second opinion or ignore it if they disagree. That makes the services seem less coercive than restrictive HMO rules. It also means companies sometimes struggle to get workers to use them. "One of the biggest knocks on this is no matter how much you communicate this, at the time the employee needs this, they may not remember that that service is available to them," says Shari Davidson, vice president of health-care cost and delivery at the National Business Group on Health, a nonprofit alliance of large employers.

A group of Pittsburgh-area school districts that buy health care together through the Allegheny County Schools Health Insurance Consortium began using Grand Rounds this spring. Outreach through mailings, a quarterly magazine, and direct prompts from Grand Rounds based on peoples’ medical claims have gotten 15 people to use the second-opinion service so far, says Jan Klein, the group’s trustee chairman. "We can’t force it on people," she says. "Well, we could. But we don’t."

At least one employee avoided a surgery after the expert reviewer "said absolutely not a good thing to do, not justified, no research that this operation will help this person," Klein says. Though she expects the service to save money, Klein says getting people the proper diagnosis and treatment is more important. "Sometimes their costs are more than it would have been under the wrong diagnosis," she says, "but they would have been treated for the wrong thing."



Correction: Corrects number of people who have used the second-opinion service through the Allegheny County Schools Health Insurance Consortium




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Fear Not, Science will save Mankind from aging.


A Ray of Hope for Reversing Degenerative Blindness
. . .

Hope for Blindness

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Image Credit: Jenn Turner. Flickr.com
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A new, engineered light-activated protein holds promise for restoring sight to millions of people blinded by progressive degeneration of light-sensing cells in the outer retina. As reported in research published by PLOS Biology, the method is the first to overcome the obstacles of low light sensitivity and incompatibility with normal signaling mechanisms that exist with other genetic approaches to restore function in these cells.

Sonja Kleinlogel’s team at the University of Bern engineered a protein that responds to daylight and subsequently activates a signaling pathway in healthy cells in the inner retina that normally don’t respond to light. The chimeric protein includes components of the photopigment melanopsin and the glutamate receptor mGluR5.

The researchers say their approach meets several criteria for a potential gene therapy for patients with photoreceptor degeneration. In mice, it restores light sensitivity at environmental light levels; it is physiologically compatible with no toxic or immunogenic side effects; and with the current state of intravitreal injection, it is a minimally invasive and safe technology.

With a globally aging population, the availability of new approaches to treat diseases associated with aging is increasingly important.

Congratulations to PLOS Biology corresponding author, Sonja Kleinlogel, whose discovery forming the basis of this research article received the 2013 Euretina Science & Medicine Innovation Award.

Read More:
Restoring vision with a new optogenetic tool

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Focusing the Brain on Better Vision


CreditSophia Martineck

Focusing the Brain on Better Vision
By JAN HOFFMAN APRIL 6, 2015 5:16 PM April 6, 2015


As adults age, vision deteriorates. One common type of decline is in contrast sensitivity, the ability to distinguish gradations of light to dark, making it possible to discern where one object ends and another begins.

When an older adult descends a flight of stairs, for example, she may not tell the edge of one step from the next, so she stumbles. At night, an older driver may squint to see the edge of white road stripes on blacktop. Caught in the glare of headlights, he swerves.

But new research suggests that contrast sensitivity can be improved with brain-training exercises. In a study published last month in Psychological Science, researchers at the University of California, Riverside, and Brown University showed that after just five sessions of behavioral exercises, the vision of 16 people in their 60s and 70s significantly improved.

After the training, the adults could make out edges far better. And when given a standard eye chart, a task that differed from the one they were trained on, they could correctly identify more letters.

“There’s an idea out there that everything falls apart as we get older, but even older brains are growing new cells,” said Allison B. Sekuler, a professor of psychology, neuroscience and behavior at McMaster University in Ontario, who was not involved in the new study. “You can teach an older brain new tricks.”

The training improved contrast sensitivity in 16 young adults in the study as well, although the older subjects showed greater gains. That is partly because the younger ones, college students, already had reasonably healthy vision and there was not as much room for improvement.

Before the training, the vision of each adult, young and older, was assessed. The exercises were fine-tuned at the beginning for each individual so researchers could measure improvements, said Dr.G. John Andersen, the project’s senior adviser and a psychology professor at the University of California, Riverside.

During each session, the subjects watched 750 striped images that were rapidly presented on a computer screen with subtle changes in the visual “noise” surrounding them — like snow on a television. The viewer indicated whether the images were rotating clockwise or counterclockwise. The subject would hear a beep for every correct response.

Each session took an hour and a half. The exercises were taxing, although the subjects took frequent breaks. But after five sessions, the subjects had learned to home in more precisely on the images and to filter out the distracting visual noise. After the training, the older adults performed as well as those 40 years younger, before their own training.

The older participants were also better able to make out letters on an eye chart at reading distance, although not one 10 feet away. The younger students were better able to see the distant eye chart, but not the closer one.

“We think that a behavioral intervention where learning is going on changes brain structure in older adults,” Dr. Andersen said.

In the absence of a disease like glaucoma or changes in the retina and optic nerve, contrast sensitivity is processed by the brain’s visual cortex. This study suggests that certain areas of the brain can be strengthened. “It means the visual system has a high degree of plasticity, even in old age,” Dr. Andersen said.

Dr. Andersen and his colleagues, including Denton DeLoss, a graduate student and the paper’s lead author, say they do not know how long the effects of this modest intervention will last. But an earlier study in which older adults received training to sharpen their ability to discern texture showed that the improvement was sustained for at least three months.

Dr. Andersen said that as people aged, the random firing of neurons in the brain’s visual system increased, creating a kind of internal noise. At the same time, the aging brain struggles harder with external visual noise, such as snowflakes in a blizzard that obscure words on a road sign.

The latest study’s exercises were designed to train adults to filter such external visual noise so they could better discern edges of contrast. “It’s possible that the brain might simultaneously have been trained to reduce internalized noise,” Dr. Andersen said.

Researchers are increasingly focused on perceptual learning, the brain’s ability to discriminate among stimuli — training the ear, for example, to distinguish between Shostakovich and Bartok, or the palate to discern a cabernet sauvignon from a pinot noir. There is also much research on the aging brain. But until now, few scientists have thought to examine the possibilities for improving perceptual learning in older adults.

“These researchers are leading the charge,” Dr. Sekuler said.


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A version of this article appears in print on 04/07/2015, on page D5 of theNewYork edition with the headline: Focusing the Brain on Better Vision.


AGING, BODY, BRAIN, ELDERLY, EYES AND EYESIGHT



 

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MDR Tuberculosis


The White House has a plan to combat multidrug-resistant tuberculosis, but it may never get funded.



"Tuberculosis is the disease we thought HIV would be in the '80s. A disease you could get and die from that was aerosolized and spread through the air," Eric Goosby, the U.N. special envoy on tuberculosis, said at a United Nations Foundation briefing in July. "With TB, you can get it standing in a line when you go to the grocery store or standing in line for the movies."

The highly infectious bacteria that cause TB spread in tiny droplets of saliva and mucous that are expelled when an infected person coughs. They can float in the air for hours. 

About one-third of the world's population is infected with tuberculosis. The lucky ones have strong enough immune systems to wall off the TB bacteria, forcing it to lie dormant. The unlucky ones -- about 10 percent of those infected -- come down with a wracking cough, overwhelming weakness, weight loss and persistent fatigue. 

If left untreated, two-thirds of people with active TB die. It is the No. 2 single-agent infectious killer in the world (behind HIV/AIDS), according to the World Health Organization, and the No. 1 killer of those infected with HIV/AIDS.


Read more: http://www.stumbleupon.com/to/stumble/stumblethru:huffingtonpost.com



Thursday, October 1, 2015

The Neuroscience of Happiness

Uploaded on Jul 1, 2011

Is happiness a skill? Modern neuroscientific research and the wisdom of ancient contemplative traditions converge in suggesting that happiness is the product of skills that can be enhanced through training and such training exemplifies how transforming the mind can change the brain. 

Kent Berridge, Richie Davidson, and Daniel Gilbert speak at the Aspen Ideas Festival
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